In summary
Dr. Mohammed Wael Daboul (D.D.S, MSc. Biology, MT- Ascp, Laboratory Medicine specialist.)
A Study of the correlation in the elevation of , Glucose , cholesterol and triglyceride in human plasma
This research paper introduces a scientific study with a statistical manner to evaluate the correlation and relationship among the three parameters , Glucose , cholesterol and triglyceride through their concentration in blood and the effect of concentration change of one of the parameters, on the others. We have chosen our sample which counts 438 individuals males and females who attended our lab for either periodical checkup or type (2) diabetes patients, excluding those who are under insulin treatment , and diabetic type (1) patients. The purpose of that exclusion is to restrict the influential factors in our study and to concentrate on relationship of the three parameters mentioned above. 27 specimen have been studied which carried out all the possible correlations among the three parameters . In each specimen , we compared the three different categories according to the following hypothesis ( there is no significant difference among the elevated cases in the category A, or B, or C under 5% level of significance and under (x) degree of freedom .) . We used the CHI- SQUARE test as away of analyzing our data and confirming or rejecting the hypothesis.
Our research results came into the following conclusions:
1- On normal non diabetic individual, there is a correlation between the triglyceride and cholesterol , as the elevation in cholesterol concentration in plasma is associated with an increase cases of triglyceride elevation over 150 mg/dl in blood and vies versa , the elevation in triglyceride concentration in is associated with an increase cases of cholesterol elevation over 200 mg/dl in plasma .
2- In diabetic patients , ( glucose > 110 mg/ dl ) the study showed that ,elevation in triglyceride concentration will not be necessarily associated with an increase cases of cholesterol elevation over 200 mg/dl in plasma , and the elevation in cholesterol concentration in plasma will not be necessarily associated with an increase cases of triglyceride elevation over 150 mg/dl in blood.( but according to the tow tables in specimen 2 and 3 , the results show that, the elevation in cholesterol concentration in plasma is associated with an increase cases of triglyceride elevation over 150 mg/dl in blood , but any how , the the CHI- SQUARE test showed no significant difference ) . We conclude that in diabetic situation , cholesterol and triglyceride elevation act independently and not necessarily in correlation ( table specimen 4 , 8).
3- 3-The elevation of cholesterol concentration alone , will have no effect on increasing the elevated glucose cases in plasma , which means that the elevation in glucose is independent from the cholesterol concentration alone in blood, so our studies did not prove any direct relation between cholesterol and its effect on diabetes ( specimen table 9,10,11,12).
4- Glucose elevation in blood has an effect on the increase cases of elevated triglyceride in blood > 150 mg/dl ( once the cholesterol concentration is normal < 201 mg/dl) . but once the cholesterol is elevated > 200 mg/dl , then our study conclude no direct effect for glucose elevation alone on the increase cases of elevated triglycerides ( specimen table 13,14,15,16).
5- No direct correlation between glucose elevation and the elevation in the number of cases of cholesterol elevated > 200 mg/dl no matter what the triglyceride concentration is. That concludes that diabetes alone , should not be considered a cause for cholesterol elevation in plasma.(table 17,18,19,20
6- Our Statistical results tells that the elevation in triglyceride concentration in plasma, is strongly correlated with elevation in the number of cases of glucose elevated > 110 mg/dl no matter what the cholesterol concentration is , which means , that triglyceride alone regardless of cholesterol , is strongly related with diabetes development. ( specimen , table 21,22,23,24 ).
8- 7-Our study also has shown that , the combination of elevation of any of the two parameters mentioned , should absolutely associate with the elevation in the number of cases of the elevated concentration of the third factor where we see :
A- The combination elevation in both triglyceride and cholesterol concentration is associated with increase cases of glucose elevated > 110 mg/dl ( specimen , table 25) .
B- And The combination elevation in both triglyceride and glucose concentration is associated with increase cases of cholesterol elevated > 200 mg/dl ( specimen , table26) .
C- And The combination elevation in both cholesterol and glucose concentration is associated with
increase cases of elevated triglyceride > 150 mg/dl ( specimen , table27) .